CDD research
Selected Publications

2014 - Publications to Date: 1

Avraham HK, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Zvonok A, Masliah E, Avraham S. (2014) The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. Br. J. Pharmacol., In Press. PMID: 24148086 View Article

2013 - Total Publications: 15

Chopda GR, Vemuri VK, Sharma R, Thakur GA, Makriyannis A, Paronis CA. 2013 Diuretic effects of cannabinoid agonists in mice. Eur. J. Pharmacol. 721(1-3), 64-9. PMID: 24099963 View Article

Fichna J, Wood JT, Papanastasiou M, Vadivel SK, Oprocha P, Sałaga M, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Małecka-Panas E, Krajewska WM, Kościelniak P, Makriyannis A, Storr MA. (2013) Endocannabinoid and Cannabinoid-Like Fatty Acid Amide Levels Correlate with Pain-Related Symptoms in Patients with IBS-D and IBS-C: A Pilot Study. PLoS One 8(12), e85073. PMID: 24386448 View Article

Gamaleddin I, Guranda M, Scherma M, Fratta W, Makriyannis A, Vadivel SK, Goldberg SR, Le Foll B. (2013) AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking. J. Psychopharmacol., 27(6): 564-71. View Article

Järbe TU, Lemay BJ, Halikhedkar A, Wood J, Vadivel SK, Zvonok A, Makriyannis A. (2013) Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats. Psychopharmacology (Berl), 52(29), 5016-26. PMID: 24005529 View Article

Kangas BD, Delatte MS, Vemuri VK, Thakur GA, Nikas SP, Subramanian KV, Shukla VG, Makriyannis A, Bergman J. (2013) Cannabinoid Discrimination and Antagonism by CB1 Neutral and Inverse Agonist Antagonists. J. Pharmacol. Exp. Ther., 344(3): 561-7. PMID: 23287700 PMCID: PMC 3583508 View Article

Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. (2013) Active-Site Inhibitors Modulate the Dynamic Properties of Human Monoacylglycerol Lipase: A Hydrogen Exchange Mass Spectrometry Study. Biochemistry, In Press. PMID: 23795559 View Article

Le Foll B, Pushparaj A, Pryslawsky Y, Forget B, Vemuri VK, Makriyannis A, Trigo JM. (2013) Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach. Prog Neuropsychopharmacol Biol Psychiatry. In Press. PMID: 24140878 View Article

Li H, Wood J, Whitten K, Vadival S, Seng S, Makriyannis A, Avraham S, Avraham H. (2013) Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells. Br. J. Pharmcol. 170(3), 489-505. PMID: 23347118 View Article

Marcu J, Shore DM, Kapur A, Trznadel M, Makriyannis A, Reggio PH, Abood ME. (2013) Novel Insights Into CB1 Cannabinoid Receptor Signaling: A Key Interaction Identified Between EC3-Loop and TMH2. J. Pharmacol Exp. Ther., 345(2): 189-97. PMID: 23426954 PMCID: PMC3629795 View Article

McLaughlin PJ, Thakur GA, Vemuri VK, McClure ED, Brown CM, Winston KM, Wood JT, Makriyannis A, Salamone JD. (2013) Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054. Pharmacol Biochem Behav. 109, 16-22. PMID: 23603029 View article

Miller RL, Thakur GA, Stewart WN, Bow JP, Bajaj S, Makriyannis A, McLaughlin PJ. 2013 Effects of a novel CB1 agonist on visual attention in male rats: role of strategy and expectancy in task accuracy. Exp. Clin. Psychopharmacol. 21(5), 416-25. PMID: 24099361 View Article

Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. (2013) Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci.> 22(6), 774-87. PMID: 23553709 View Article

Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A. (2013) Controlled-deactivation cannabinergic ligands. J. Med. Chem. 56(24), 10142-57. PMID: 24286207 View Article

Zhuang J, Yang DP, Nikas SP, Zhao J, Guo J, Makriyannis A. (2013) The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using (19) F-NMR. AAPS, 15(2), 477-82. PMID: 23344792 PMCID: PMC3675727 View Article

Zhuang J, Yang DP, Tian X, Nikas SP, Sharma R, Guo JJ, Makriyannis A. (2013) Targeting the Endocannabinoid System for Neuroprotection: A 19F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HAS. J. Pharmaceutics Pharmacol., In Press. View Article

2012 - Total Publications: 26

Alapafuja SO, Nikas SP, Bharatan I, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A. (2012) Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase.  J. Med. Chem., 55(22): 10074-10089 View article

Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, Makriyannis A, Davison JS, Sharkey KA. (2012) Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. Br J Pharmacol. 165(5):1556-71 View article

Bowman AL, Makriyannis A. (2012) Highly predictive ligand-based pharmacophore and homology models of ABHD6, Chem. Biol. Drug Des., In Press View article

Deng L, Guindon J, Vemuri VK, Thakur GA, White FA, Makriyannis A, Hohmann AG. (2012) The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.  Mol Pain., 8(1): 71 View article

Dixon DD, Tius MA, Thakur GA, Zhou H, Bowman AL, Shukla VG, Peng Y, Makriyannis A. (2012) C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.  Bioorg. Med. Chem., 22(16): 5322-5325  View article

Gamaleddin I, Zvonok A, Makriyannis A, Goldberg SR, LeFoll B. (2012) Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self-administration and reinstatement of nicotine seeking.  PLoS One, 7(1): e29900 View article

Gunduz-Cinar O, Macpherson KP, Cinar R, Gamble-George J, Sudgen K, Williams B, Godlewski G, Ramilkie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A. (2012) Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol. Psychiatry, In Press View article

Järbe TU, Tai S, Lemay BJ, Nikas SP, Shukla VG, Zvonok A, Makriyannis A. (2012) AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice. Psychopharmacology (Berl). 220(2):417-26 View article

Jonhston M, Bhatt SR, Sikka S, Mercier RW, West JM, Makriyannis A, Gatley SJ, Duclos RI Jr. (2012) Assay inhibition of diacylglycerol lipase activity.  Bioorg. Med. Chem. Lett., 22(14): 4585-4592 View article

Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. (2012) Endocannabinoid enzyme engineering: Soluble human thio-monoacylglycerol lipase (sol-S-hMGL).  ACS Chem Neuroscience., 3(5): 393-399 View article

Lu D, Nikas SP, Han X-W, Parrsh DA, Makriyannis A. (2012) Snythesis and characterization of a compact tricyclic resorcinol from (+)- and (-)-3-pinanol. Tetrahedron Lett., 53:4636-4638 View article

Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon PM, Graves EE, Shukla V, Makriyannis A, Bahr BA. (2012) Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology.  Neurotherapeutics, 9(4): 801-813 View article

Nikas SP, D'Souza M, Makriyannis A. (2012) Enantioselective snythesis of (10S)- and (10R)-methyl-anandamides. Tetrahedron, 68: 6329-6337 View article

Paronis CA, Nikas SP, Shukla VG, Makriyannis A. (2012) Δ9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice.  Behav. Pharmacol., 23(8): 802-80 5 View article

Paronis C, Thakur GA, Bajaj S, Nikas SP, Vemuri VK, Makriyannis A, Bergman J. (2012) Diuretic effects of cannabinoids.  J. Pharmacol. Exp. Ther., In Press View article

Randall PA, Pardo M, Nunes EJ, López Cruz L, Vemuri VK, Makriyannis A, Baqi Y, Müller CE, Correa M, Salamone JD. (2012) Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.  PloS One, In Press View article

Reichenbach V, Ros J, Fernández-Varo G, Casals G, Melgar-Lesmes P, Campos T, Makriyannis A, Morales-Ruiz M, Jiménez W. (2012) Prevention of fibrosis progression in CCl4-treated rats: role of the hepatic endocannabinoid and apelin systems. J Pharmacol Exp Ther. 340(3):629-37 View article

Scherma M, Justinova Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W,  Makriyannis A, Vadivel SK, Gamaleddin I, LeFoll B, Goldberg SR. (2012) The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.  Br. J. Pharmacol., 165(8): 2539-2548 View article

Shen L, Huang H, Makriyannis A, Fisher LS. (2012) Integrated ligand based pharmacophore model derived from diverse FAAH covalent ligand classes. Curr. Comput. Aided Drug Des., In Press View article

West JM, Zvonok N, Whitten KM, Vadivel SK, Bowman AL, Makriyannis A. (2012) Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing Acid amidase inhibition. PLoS One, 7(8): e43877 View article

West JM, Zvonok N, Whitten KM, Wood JT, Makriyannis A. (2012) Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase. J Proteome Res. 11(2):972-81 View article

Whitten KM, Makriyannis A, Vadivel SK. (2012) Application of chemoenzymatic hydrolysis in the synthesis of 2-monoacylglycerols. Tetrahedron., 68(27-28): 5422-5428 View article

Whitten K, Makriyannis A, Vadivel SK. (2012) Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters.  Tetrahedron., 53(43): 5753-5755 View article

Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Armijo LM, Kuhm MN, Thakur GA, Makriyannis A, Milligan ED. (2012) Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia. Brain Beh., 2(2): 155-177 View article

Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Armijo LM, Kuhn MN,  Thakur GA, Makriyannis A, Milligan ED. (2012) Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels.  Pain, 153(5): 1091-1106 View article

Wood JT, Smith DM, Janero DR, Zvonok AM, Makriyannis A. (2012) Therapeutic modulation of cannabinoid lipid signaling: Metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist. Life Sci., In Press View article

2011 - Total Publications: 17

Bowman AL, Makriyannis A. (2011) Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH). J Chem Inf Model. 51(12):3247-3253 View article

Cluny NL, Chambers AP, Vemuri VK, Wood JT, Eller LK, Freni C, Reimer RA, Makriyannis A, Sharkey KA. (2011) The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. Pharmacol Biochem Behav. 97(3):537-543 View article

Duclos RI Jr, Johnston M, Vadivel SK, Makriyannis A, Glaser ST, Gatley SJ. (2011) A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). J Org Chem. 76(7):2049-2055 View article

Gutierrez T, Crystal JD, Zvonok AM, Makriyannis A, Hohmann AG. (2011) Self-medication of a cannabinoid CB(2) agonist in an animal model of neuropathic pain. Pain. 152(9):1976-1987 View article

Janero DR, Lindsley L, Vemuri VK, Makriyannis A. (2011) Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk. Expert Opinion on Drug Discovery 6(10):995-1025 View article

Järbe TU, Deng H, Vadivel SK, Makriyannis A. (2011) Cannabinergic aminoalkylindoles, including AM678=JWH018 found in 'Spice', examined using drug (Δ(9)-tetrahydrocannabinol) discrimination for rats. Behav Pharmacol. 22(5-6):498-507 View article

Järbe TU, LeMay BJ, Vemuri VK, Vadivel SK, Zvonok A, Makriyannis A. (2011) Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats. Psychopharmacology (Berl). 216(3):355-365 View article

Makriyannis A, Nikas SP. (2011) Aspirin-triggered metabolites of EFAs. Chem Biol. 18(10):1208-1209 View article

Naidoo V, Nikas SP, Karanian DA, Hwang J, Zhao J, Wood JT, Alapafuja SO, Vadivel SK, Butler D, Makriyannis A, Bahr BA. (2011) A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. J Mol Neurosci. 43(3):493-502 View article

Rahn EJ, Thakur GA, Wood JA, Zvonok AM, Makriyannis A, Hohmann AG. (2011) Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects. Pharmacol Biochem Behav. 98(4):493-502 View article

Seif T, Makriyannis A, Kunos G, Bonci A, Hopf FW. (2011) The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience. 193:21-33 View article

Singh SN, Bakshi K, Mercier RW, Makriyannis A, Pavlopoulos S. (2011) Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2. Biochemistry. 50(12):2223-2234 View article

Szymanski DW, Papanastasiou M, Melchior K, Zvonok N, Mercier RW, Janero DR, Thakur GA, Cha S, Wu B, Karger B, Makriyannis A. (2011) Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation. J Proteome Res. 10(10):4789-4798 View article

Teng H, Thakur GA, Makriyannis A. (2011) Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. Bioorg Med Chem Lett. 21(19):5999-6002 View article

Tian X, Pavlopoulos S, Yang DP, Makriyannis A. (2011) The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR. Biochim Biophys Acta. 1808(9):2095-2101 View article

Tiburu EK, Tyukhtenko S, Zhou H, Janero DR, Struppe J, Makriyannis A. (2011) Human cannabinoid 1 GPCR C-terminal domain interacts with bilayer phospholipids to modulate the structure of its membrane environment. AAPS J. 13(1):92-98 View article

Vadivel SK, Whitten KM, Makriyannis A. (2011) Chemoenzymatic Synthesis of 2-Arachidonoylglycerol, An Endogenous Ligand for Cannabinoid Receptors. Tetrahedron Lett. 52(11):1149-1150 View article

2010 - Total Publications: 25

Anagnostopoulos D., C. Rakiec, J. Wood, L. Pandarinathan, N. Zvonok, A. Makriyannis, A. Siafaka-Kapadai, (2010), Identification of endocannabinoids and related N-acylethanolamines in tetrahymena. A new class of compounds for tetrahymena. Protist., 161(3), 452-465. PMID: 20096629 View article 7/2010

Cluny N.L., V.K. Vemuri, A.P. Chambers, C.L. Limebeer, H. Bedard, J.T. Wood, B. Lutz, A. Zimmer, L.A. Parker, A. Makriyannis, K.A. Sharkey, (2010), A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. Br. J. Pharmacol., 161(3), 629-642. PMID: 20880401 View article 10/2010

Dixon D.D., D. Sethumadhavan, T. Benneche, A.R. Banaag, M.A. Tius, G.A. Thakur, A. Bowman, J.T. Wood, A. Makriyannis, (2010), Heteroadamantyl cannabinoids. J. Med. Chem., 53(15), 5656-5666. PMID: 20593789 View article 8/2010

Godlewski G., S.O. Alapafuja, S. Batkai, S.P. Nikas, R. Cinar, L. Offertaler, D. Osei-Hyiaman, J. Liu, B. Mukhopadhyay, J. Harvey-White, J. Tam, K. Pacak, J.L. Blankman, B.F. Cravatt, A. Makriyannis, G. Kunos, (2010), Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem. Biol., 17(11), 1256-1266. View article PMID: 21095576 11/2010

Guo J., R.I. Duclos Jr., V.K. Vemuri, A. Makriyannis, (2010), The conformations of 17β-estradiol (E2) and 17α-estradiol as determined by solution NMR Tetrahedron, 51(2010), 3465-3469. View article

Hwang J., C. Adamson, D. Butler, D.R. Janero, A. Makriyannis, B.A. Bahr, (2010), Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality. Life Sci., 86(15-16), 615-623. PMID: 19527737 View article 4/2010

Järbe T.U., R.S. Gifford, A. Makriyannis, (2010), Antagonism o delta(9)-THC induced behavioral effects by rimonabant: time course studies in rats. Eur. J . Pharmacol., 648(1-3), 133-138. PMID: 20854804 View article 9/2010

Järbe T.U., C. Li, S.K. Vadivel, A. Makriyannis, (2010), Discriminative stimulus functions of methanandamide and delta(9)-THC in rats: Tests with aminoalkyll indoles (WIN55, 212-2 and AM678) and ethanol. Psychopharmacology (Berl)., 208(1), 87-98. PMID: 19902182 View article 1/2010

Karageorgos I., S. Tyukhtenko, N. Zvonok, D. Janero, A. Makriyannis, (2010), Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglyerol lipase (hMGL): Implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism. Mol. Biosyst., 6(8), 1381-1388. PMID: 20464001 View article 8/2010

Limebeer C.L., V.K. Vemuri, H. Bedhard, S.T. Lang, K.P. Ossenkopp, A. Makriyannis, L.A. Parker, (2010), Inverse agonism of cannabinoid CB receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats. Br J Pharmacol., 161(2), 336-349. PMID: 20735419 View article 9/2010

McLaughlin P.J., K.M. Winston, L.A. Swezey, A. Makriyannis, J.D. Salamone, (2010), Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonists and dopamine D1 and D2 antagonists. Pharmacol. Biochem. Behav., 96(1), 75-81. PMID: 20403373 View article 7/2010

Mercier R.W., Y. Pei, L. Pandarinathan, D.R. Janero, J. Zhang, A. Makriyannis, (2010), Human cannabinoid 2 ligand-interaction landscape: Cysteine resdues critical to biarylpyrazole antagonist binding motif and receptor modulation. Chem. Biol., 17(10), 1132-1142. PMID: 21035736 View article 10/2010

Nikas, S., S.O. Alapafuja, I. Papanastasiou, C.A. Paronis, V.G. Shukla, D.P. Papahatjis, A.L. Bowman, A. Halikhedkar, X. Han, A. Makriyannis, (2010), Novel 1',1'-chain substituted hexahydrocannabinols: 9β-Hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. J. Med. Chem., 53(19), 6996-7010. PMID: 20925434 View article 10/2010

Papahatijis D.P., V.R. Nahmias, S.P. Nikas, M. Schimpgen, A. Makriyannis, (2010), Design and synthesis of (13S)-methy-substituted arachidonic acid analogues: Templates for novel endocannabinoids. Chemistry, 16(13), 4091-4099. PMID: 20187040 View article 4/2010

Rahn E.J., A.M. Zvonok, A. Makriyannis, A.G. Hohmann, (2010), Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: Lack of dependence upon opioid receptor activation. AAPS J. 12(2), 147-157. PMID: 20127295 View article 6/2010

Randall P.A., V.K. Vemuri, K.N. Segovia, E.F. Torres, S. Hosmer, E.J. Nunes, J.L. Santerre, A. Makriyannis, J.D. Salamone, (2010), The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior. Pharmacol. Biochem. Behav., 97(1), 179-184. PMID: 20713079 View article 11/2010

Schindler C.W., L.V. Panlilio, J.P. Gilman, Z. Justinova, V.K. Vemuri, A. Makriyannis, S.R. Goldberg, (2010), Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys. Eur. J. Pharmacol., 633(1-3), 44-49. PMID: 20153314 View article 5/2010

Selvakumar J., A. Makriyannis, C.R. Ramanathan, (2010), An unusual reactivity of BBR(3): Accessing tetrahydroisoquinoline units from N-phenethylimides. J. Org. Biomol. Chem., 8(18), 4056-4058. PMID: 20664860 View article 9/2010

Sink K.S., K.N. Segovia, P.A. Randall, L.E. Collins, M. Correa, E.J. Markus, V.K. Vemuri, A. Makriyannis, J.D. Salamone, (2010), Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142. Eur. Neuropsychopharmacol., 20(2), 112-122. PMID: 20015619 View article 2/2010

Sink K.S., K.N Segovia, L.E. Collins, E.J. Markus, V.K. Vemuri, A. Makriyannis, J.D. Salamone, (2010), The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats. Pharmacol. Biochem. Behav., 95(4), 479-484. PMID: 20347865 View article 6/2010

Storr M.A., M. Bashashati, C. Hirota, V.K. Vemuri, C.M. Keenan, M. Duncan, B. Lutz, K. Mackie, A. Makriyannis, W.K. Macnaughton, K.A. Sharkey, (2010), Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice. Neurogastroenterol Motil., 22(7), 787-796. PMID: 20180825 View abstract 7/2010

Tam J., V.K. Vemuri, J. Liu, S. Bátkai, B. Mukhopadhyay, G. Godlewski, D. Osei-Hyiaman, S. Ohnuma, S.V. Ambudkar, J. Pickel, A. Makriyannis, G. Kunos, (20100 ), Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J. Clin. Invest., 120(8), 2953-2966. PMID: 20664173 View article 8/2010

Vishnumurthy K., A. Makriyannis, (2010), Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling. J. Comb. Chem., 12(5), 664-669. PMID: 20831265 View article

Wood J.T., J.S. Williams, L. Pandarinathan, D.R. Janero, C.J. Lammi-Keefe, A. Makriyannis, (2010), Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma. J. Lipid Res., 51(6), 1416-1423. PMID: 20071693 View article 6/2010

Zvonok N., W. Xu, J. Williams, D.R. Janero, S.C. Krishnan, A. Makriyannis, (2010), Mass spectrometry-based GPCR proteomics: Comprehensive characterization of the human cannabinoid 1 receptor. J. Proteome Res., 9(4), 1746-1753. PMID: 20131867 View article 4/2010

2009 - Total Publications: 16

Alapafuja S.O., S.P. Nikas, V.G. Shukla, I. Papanastasiou, A. Makriyannis, (2009), Microwave assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides. Tetrahedron Lett., 50(50), 7028-7031. PMID: 21132105 View article 12/2009

Bowman A.L., A. Makriyannis, (2009), Refined homology model of monoacylglycerol lipase: Toward a selective inhibitor. J. Comput. Aided Mol. Des., 23(11), 799-806. PMID: 19543978 View article 11/2009

Janero D.R., A. Makriyannis, (2009), Cannabinoid receptor antagonists: Pharmacological opportunities, clinical experience, and translational prognosis. Expert Opin. Emerg. Drugs, 14(1), 43-65. PMID: 19249987 View article 3/2009

Janero D.R., S.K. Vadivel, A. Makriyannis, (2009), Pharmacotherapeutic modulation of the endocannabinoid signaling system in psychiatric disorders: Drug-discovery strategies. Int. J. Psychiatry, 21(2), 122-133. PMID: 19367506 View article 4/2009

Järbe T.U., C. Li, Q. Liu, A. Makriyannis, (2009), Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. PP sychopharmacology (Berl)., 203(2), 229-239. PMID: 18521574 View article 4/2009

Kunos G., D. Osei-Hyiaman, S. Bátkai, K.A. Sharkey, A. Makriyannis, (2009), Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol. Sci., 30(1), 1-7. PMID: 19042036 View article 1/2009

Sharma, R. K.V. Subramanian, R.I. Duclos Jr., A. Makriyannis, (2009), Open vessel mode microwave-assisted synthesis of 2-oxazolines from carboxylic acids. Tetrahedron, 50(2009), 5780-5782. View article

Sink K.S., K.N. Segovia, E.J. Nunes, L.E. Collins, V.K. Vemuri, G.A. Thakur, A. Makriyannis, J.D. Salamone, (2009), Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology (Berl)., 206(2), 223-232. PMID: 19588124 View article 10/2009

Sink K.S., V.K. Vemuri, J.T. Wood, A. Makriyannis, J.D. Salamone, (2009), Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527: Effects on food-reinforced behavior and comparisons with AM4113. Pharmacol. Biochem. Behav., 91(3), 303-306. PMID: 18703081 View article 1/2009

Storr M.A., C.M. Keenan, H. Zhang, K.D. Patel, A. Makriyannis, K.A. Sharkey, (2009), Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. Inflamm. Bowel Dis., 15(11), 1678-1685. PMID: 19408320 View article 11/2009

Thakur G.A., R. Tichkule, S. Bajaj, A. Makriyannis, (2009), Latest advances in cannabinoid receptor agonists. Expert Opin. Ther. Pat., (19)12, 1647-1673. PMID: 19939187 View article 12/2009

Tiburu E.K., A.L. Bowman, J.O. Struppe, D.R. Janero, H.K. Avraham, A. Makriyannis, (2009), Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes. Biochim. Biophys. Acta., 1788(5), 1159-1167. PMID: 19366584 View article 5/2009

Tiburu E.K., S.V. Gulla, M. Tiburu, D.R. Janero, D.E. Budil, A. Makriyannis, (2009), Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment. Biochemistry, 48(22), 4895-4904. PMID: 19485422 View article 6/2009

Tiburu E.K., S. Tyukhtenko, L. Deshmukh, O. Vinogradova, D.R. Janero, A. Makriyannis, (2009), Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. Biochem. Biophys. Res. Commun., 384(2), 243-248. PMID: 19397896 View article 6/2009

Tyukhtenko S., E.K. Tiburu, L. Deshmukh, O. Vinogradova, D.R. Janero, A. Makriyannis, (2009), NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: Candidates electrostatic interactions and microdomain formation. Biochem. Biophys. Res. Commun., 390(3), 441-446. PMID: 19766594 View article 12/2009

Willmore C.B., D.M. Krall, F.M. Spears, A. Makriyannis, G.I. Elmer, (2009), Cognitive effects of psychotomimetic drugs in rats discriminating number cues. Psychopharmacology (Berl.), 206(4), 653-664. PMID: 18843483 View article 11/2009

2008 - Total Publications: 20

Bergman J., M.S. Delatte, C.A. Paronis, V.K. Vemuri, G.A. Thakur, A. Makriyannis, (2008), Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties. Physiol. Behav., 93(4-5), 666-670. PMID: 18076956 View article 3/2008

Duclos Jr., R.I., D. Lu, J. Guo, A. Makriyannis, (2008), Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands. Tetrahedron, 49(39), 5587-5589.

Guo J., D.P. Yang, R. Chari, X. Tian, S. Pavlopoulos, D. Lu, A. Makriyannis, (2008), Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers. J. Med. Chem., 51(21), 6793-6799. PMID: 18834109 View article 11/2008

Hodge J., J.P. Bow, K.S. Plyler, V.K. Vemuri, A. Wisniecki, J.D. Salamone, A. Makriyannis, P.J. McLaughlin, (2008), The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats. Behav. Brain Res., 193(2), 298-305. PMID: 18602425 View article 11/2008

Järbe T.U.C., B.J. Lemay, T. Olszewska, V.K. Vemuri, J.T. Wood, A. Makriyannis, (2008), Intrinsic effects of AM4113, a putative neutral CB1 receptor selectii ve antagonist, on open-field behaviors in rats. Pharmacol. Biochem. Behav., 91(1), 84-90. PMID: 18640150 View article 11/2008

Järbe T.U.C., C. Li, S.K. Vadivel, A. Makriyannis, (2008), Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats. Psychopharmacology (Berl.), 198(4), 467-478. PMID: 18264696 View article 7/2008

Kapur A., P. Samaniego, G.A. Thakur, A. Makriyannis, M.E. Abood, (2008), Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction. J. Pharmacol. Exp. Ther., 325(1), 341-348. PMID: 18174385 View article 4/2008

Lu D., J. Guo, R.I. Duclos Jr., A.L. Bowman, A. Makriyannis, (2008), Bornyl- and isobornyl-~H~F8-tetrahydrocannabinols: A novel class of cannabinergic ligands. J. Med. Chem., 51(20), 6393-6399. PMID: 18826296 View article 10/2008

Lu T.S., H.K. Avraham, S. Seng, S.D. Tachado, H. Koziel, A. Makriyannis, S. Avraham, (2008), Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J. Immunol., 181(9), 6406-6416. PMID: 18941231 View article 11/2008

Magriotti V., G. Naxakis, D. Hadjipavlou-Litina, A. Makriyannis, G. Kokotos, (2008), A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity. Bioorg. Med. Chem. Lett., 18(20), 5424-5427. PMID: 18819796 View article 10/2008

Pei Y., R.W. Mercier, J.K. Anday, G.A. Thakur, A.M. Zvonok, D. Hurst, P.H. Reggio, D.R. Janero, A. Makriyannis, (2008), Ligand-binding architecture of human CB2 cannabinoid receptor: Evidence for receptor subtype-specific binding motif and modeling GPCR activation. Chem. Biol., 15(11), 1207-1219. PMID: 19022181 View article 11/2008

Rahn E.J., A.M. Zvonok, G.A. Thakur, A.D. Khanolkar, A. Makriyannis, A.G. Hohmann, (2008), Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. J. Pharmacol. Exp. Ther., 327(2), 584-591. PMID: 18664590 View article 11/2008

Scherma M., J. Medalie, W. Fratta, S.K. Vadivel, A. Makriyannis, D. Piomelli, E. Mikies, J. Haller, S. Yasar, G. Tanda, S.R. Goldberg, (2008), The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology, 54(1), 129-140. PMID: 17904589 View article 1/2008

Sink K.S., P.J. McLaughlin, J.A. Wood, C. Brown, P. Fan, V.K. Vemuri, Y. Peng, T. Olszewska, G.A. Thakur, A. Makriyannis, L.A. Parker, J.D. Salamone, (2008), The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology, 33(4), 946-955. PMID: 17581535 View article 3/2008

Sink K.S., V.K. Vemuri, T. Olszewska, A. Makriyannis, J.D. Salamone, (2008), Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior. Psychopharmacology (Berl.), 196(4), 565-574. PMID: 18004546 View article 3/2008

Vemuri V.K., D.R. Janero, A. Makriyannis, (2008), Pharmacotherapeutic targeting of the endocannabinoid signaling system: Drugs for obesity and the metabolic syndrome. Physiol. Behav., 93(4-5), 671-686. PMID: 18155257 View article 3/2008

Wood J.T., J.S. Williams, L. Pandarinathan, A. Courville, M.R. Keplinger, D.R. Janero, P. Vouros, A. Makriyannis, C.J. Lammi-Keefe, (2008), Comprehensive profiling of the human circulating endocannabinoid metabolome: Clinical sampling and sample storage parameters. Clin. Chem. Lab. Med., 46(9), 1289-1295. PMID: 18611105 View article 2008

Yao F., C. Li, S.K. Vadivel, A.L. Bowman, A. Makriyannis, (2008), Development of novel tail-modified anandamide analogs. Bioorg. Med. Chem. Lett., 18(22), 5912-5915. PMID: 18723350 View article 11/2008

Zvonok N., J. Williams, M. Johnston, L. Pandarinathan, D.R. Janero, J. Li, S.C. Krishnan, A. Makriyannis, (2008), Full mass spectrometric characterization of human monoacyglicerol lipase generated by large-scale expression and single-step purification. J. Proteome Res., 7(5), 2158-2164. PMID: 18452279 View article 5/2008

Zvonok N., L. Pandarinathan, J. Williams, M. Johnston, I. Karageorgos, D.R. Janero, S.C. Krishnan, A. Makriyannis, (2008), Covalent inhibitors of human monoacylglycerol lipase: Ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis. Chem. Biol., 15(8), 854-862. PMID: 18721756 View article 8/2008

2007 - Total Publications: 17

Chambers A.P., V.K. Vemuri, Y. Peng, J.T. Wood, T. Olzewska, Q.J. Pittman, A. Makriyannis, K. Sharkey, (2007), A neutral CB1 receptor antagonist reduces weight gain in rat. Am. J. Physiol. Regul. Integr. Comp. Physiol., 293(6), R2185-2193. PMID: 17959701 View article 12/2007

Gutierrez T., J.N. Farthing, A.M. Zvonok, A. Makriyannis, A.G. Hohmann, (2007), Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: A comparative analysis. Br. J. Pharmacol., 150(2), 153-163. PMID: 17160008 View article 1/2007

Jiang S., Y. Fu, J. Williams, J.T. Wood, L. Pandarinathan, S. Avraham, A. Makriyannis, S. Avraham, H.K. Avraham, (2007), Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS ONE, 2(7), e641. PMID: 17653268 View article 7/2008

Järbe T.U.C., N.V. Dipatrizio, C. Li, A. Makriyannis, (2007), Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behh avior in rats. Behav. Pharmacol., 18(7), 673-680. PMID: 17912052 View article 11/2007

Janero D.R., A. Makriyannis, (2007), Targeted modulators of the endogenous cannabinoid system: Future medications to treat addiction disorders and obesity. Curr. Psych. Report, 9(5), 365-373. PMID: 17905075 View article 10/2007

Kapur A., D.P. Hurst, D. Fleischer, R. Whitnell, G.A. Thakur, A. Makriyannis, P.H. Reggio, M.E. Abood, (2007), Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: Evidence for a serine induced bend in CB1 transmembrane helix 7. Mol. Pharmacol., 71(6), 1512-1524. PMID: 17384224 View article 6/2007

Karanian D.A., S.L. Karim, J.T. Wood, J.S. Williams, S. Lin, A. Makriyannis, B.A. Bahr, (2007), Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage. J. Pharmacol. Exp. Ther., 322(3), 1059-1066. PMID: 17545313 View article 9/2007

Khanolkar A.D., D. Lu, M. Ibrahim, R.I. Duclos Jr., G.A. Thakur, T.P. Malan Jr., F. Porreca, V. Veerappan, X. Tian, C. George, D.A. Parrish, D.P. Papahatjis, A. Makriyannis, (2007), Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity. J. Med. Chem., 50(26), 6493-6500. PMID: 18038967 View article 12/2007

Makriyannis A., (2007), Cannabinoids as therapeutics. J. Med. Chem., 50(19), 4785.

Nikas S.P., G.A. Thakur, D. Parish, S.O. Alapafuja, M.A. Huestis, A. Makriyannis, (2007), A concise methodology for the synthesis of (-)-δ9-tetrahydrocannaabinol and (-)-δ 9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs. Tetrahedron, 63, 8112-8123.

Papahatjis D.P., V.R. Nahmias, S.P. Nikas, T. Andreou, S.O. Alapafuja, A. Tsotinis, J. Guo, P. Fan, A. Makriyannis, (2007), C1'-Y-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. J. Med. Chem., 50(17), 4048-4060. PMID: 17672444 View article 8/2007

Rahn E.J., A. Makriyannis, A.G. Hohmann, (2007), Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats. Br. J. Pharmacol., 152(5), 765-777. PMID: 17572696 View article 11/2007

Salamone J.D., P.J. McLaughlin, K.S. Sink, A. Makriyannis, L.A. Parker, (2007), Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions. Physiol. Behav., 91(4), 383-388. PMID: 17521686 View article 7/2007

Solinas M., G. Tandy, Z. Justinova, C.E. Wertheim, S. Yasar, D. Piomelli, S.K. Vadivel, A. Makriyannis, S.R. Goldberg, (2007), The endogenous cannabinoid anandamide produces δ-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. J. Pharmacol. Exp. Ther., 321(1), 370-380. PMID: 17210800 View article 4/2007

Vadivel S.K., S. Vardarajan, R.I. Duclos Jr., J.T. Wood, J. Guo, A. Makriyannis, (2007), Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorg. Med.Chem Lett., 17(21), 5959-5963. PMID: 17826996 View article 11/2007

Williams J., J.T. Wood, L. Pandarinathan, D.A. Karanian, B.A. Bahr, P. Vouros, A. Makriyannis, (2007), Quantitative method for profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. Anal. Chem., 79(15), 5582-5593. PMID: 17600384 View article 8/2007

Zvonok N.S., J. Yaddanapudi, S. Williams, S. Dai, K. Dong, T. Rejtar, B.L. Karger, A. Makriyannis, (2007), Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. J. Proteome Res., 6(6), 2068-2079. PMID: 17472360 View article 6/2007

2006 - Total Publications: 17

Bahr B.A., D.A. Karanian, S.S. Makanji, A. Makriyannis, (2006), Targeting the endocannabinoid system in treating brain disorders. Expert Opin. Investig. Drugs, 15(4), 351-365. PMID: 16548785 View abstract 4/2006

Chen J.Z., X.W. Han, Q. Liu, A. Makriyannis, J. Wang, X.Q. Xie, (2006), 3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach. J. Med. Chem., 49(2), 625-636. PMID: 16420048 View article 1/2006

Dhawan J., H. Deng, S.J. Gatley, A. Makriyannis, T. Akinfeleye, M. Bruneus, A.A. Dimaio, A.N. Gifford, (2006), Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R- [125/131I] AM2233. Synapse, 60(2), 93-101. PMID: 16715483 View article 8/2006

Guo J., X. Tian, S. Pavlopoulos, A. Makriyannis, (2006), “Phospholipid bicelle membrane systems for studying drug molecules.” Handbook of Modern Magnetic Resonance, Edited by G.A. Webb & David Craik. Kluwer Academic Publishers, London, UK.

Ibrahim M.M., M.L. Rude, N.J. Stagg, H.P. Mata, J. Lai, T.W. Vanderah, F. Porreca, N.E. Buckley, A. Makriyannis, T.P. Malan Jr., (2006), CB2 cannabinoid receptor mediation of antinociception. Pain, 122(1-2), 36-42. PMID: 16563625 View article 5/2006

Järbe T.U.C., R.J. Lamb, Q. Liu, A. Makriyannis, (2006), Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356). Psychopharmacology, 188(3), 315-323. PMID: 16953384 View article 10/1006

Järbe T.U.C., Q. Liu, A. Makriyannis, (2006), Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats. Psychopharmacology (Berl.), 184(1), 36-45. PMID: 16307294 View article 1/2006

Järbe T.U.C., T. Ross, N.V. Dipatrizio, L. Pandarinathan, A. Makriyannis, (2006), Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: Open-field examination in rats. Pharmacol. Biochem. Behav., 85(1), 243-252. PMID: 16996123 View article 9/2006

Kim K., D.H. Moore, A. Makriyannis, M.E. Abood, (2006), AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. Eur. J. Pharmacol., 542(1-3), 100-105. PMID: 16781706 View article 8/2006

Koufaki M., C. Kiziridi, P. Papazafiri, A. Vassilopoulos, A. Varró, Z. Nagy, A. Farkas, A. Makriyannis, (2006), Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrythmic pharmacophores. Bioorg. Med. Chem., 14(19), 6666-6678. PMID: 16782345 View article 10/2006

Lu D., V.K. Vemuri, R.I. Duclos Jr., A. Makriyannis, (2006), The cannabinergic system as a target for anti-inflammatory therapies. Current Topics in Medicinal Chemistry, 6(13), 1401-1426. PMID: 16918457 View article 2006

McLaughlin P.J., L. Qian, J.T. Wood, A. Wisniecki, K.M. Winston, L.A. Swezey, K. Ishiwari, A.J. Betz, L. Pandarinathan, W. Xu, A. Makriyannis, J.D. Salamone, (2006), Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/ inverse agonist AM 1387. Pharmacol. Biochem. Behav., 83(3), 396-402. PMID: 16616951 View article 3/2006

Papahatjis D.P., V.R. Nahmias, T. Andreou, P. Fan, A. Makriyannis, (2006), Structural modifications of the cannabinoid side chain towards C3-aryl and 1’,1’-cycloalkyl-1’-cyano cannabinoids. Bioorg. Med. Chem. Lett., 16(6), 1616-1620. PMID: 16387492 View article 3/2006

Pavlopoulos S., G.A. Thakur, S.P. Nikas, A. Makriyannis, (2006), Cannabinoid receptors as therapeutic targets. Curr. Pharm. Des., 12(14), 1751-1769. PMID: 16712486 View article 2006

Thakur G.A., S.P. Nikas, R.I. Duclos Jr., A. Makriyannis, (2006), Methods for the synthesis of cannabinergic ligands. Melthods Mol. Med., 123, 113-148. PMID: 16506405 2006

Williams J., L. Pandarinathan, J.T. Wood, P. Vouros, A. Makriyannis, (2006), Endocannabinoid metabolomics: A novel liquid chromatography-mass spectrometry reagent for fatty acid analysis. AAPS J., 8(4), E655-660. PMID: 17233529 View article 10/2006

Willmore C.B., G.D. Kohler, A. Makriyannis, (2006), Irt>t schedule controlled behavior in ‘learned helpless’ rats: Effects from a cannabinoid agonist. Neuropharmacology, 51(1), 90-101. PMID: 16753187 View article 7/2006

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