Kunos G., D. Osei-Hyiaman, S. Batkai, K.A. Sharkey, A. Makriyannis, (2009), Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol Sci., 30, 1-7.

Sink K.S., V.K. Vemuri, J.T. Wood, A. Makriyannis, J.D. Salamone, (2009), Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527: Effects on food-reinforced behavior and comparisons with AM4113.  Pharmacol. Biochem. Behav., 91, 303-306.

Bergman J., M.S. Delatte, C.A. Paronis, V.K. Vemuri, G.A. Thakur, A. Makriyannis, (2008), Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties.  Physiol. Behav., 93(4-5), 666-670. 

Duclos R.I., D. Lu, J. Guo, A. Makriyannis, (2008), Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands.  Tetrahedron Letters, 49(39), 5587-5589. 

Guo J., D.P. Yang, R. Chari, X. Tian, S. Pavlopoulos, D. Lu, A. Makriyannis, (2008), Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers. J. Med. Chem., 51(21), 6793-6799.  

Hodge J., J.P. Bow, K.S. Plyler, V.K. Vemuri, A. Wisniecki, J.D. Salamone, A. Makriyannis, P.J. McLaughlin, (2008), The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.  Behav. Brain Res. 193(2), 298-305.   

Jarbe T.U.C., B.J. Lemay, T. Olszewska, V.K. Vemuri, J.T. Wood, A. Makriyannis, (2008), Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats.  Pharmacol. Biochem. Behav. 91(1), 84-90.   

Jarbe T.U.C., C. Li, S.K. Vadivel, A. Makriyannis, (2008), Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.  Psychopharmacology (Berl)., 198(4), 467-478.   

Kapur A., P. Samaniego, G.A. Thakur, A. Makriyannis, M.E. Abood, (2008), Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.  J. Pharmacol. Exp. Ther., 325(1), 341-348.   

Lu D., J. Guo, R.I. Duclos, A. Bowman, A. Makriyannis, (2008), Bornyl- and Isobornyl-∆8-
Tetrahydrocannabinols: A Novel Class of Cannabinergic Ligands. J. Med. Chem., J Med Chem., 51(20), 6393-9.   

Lu T., H.K. Avraham, S. Seng, S.D. Tachado, H. Koziel, A. Makriyannis, S. Avraham, (2008), Cannabinoids inhibits HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J. Immunol., 181(9), 6406-6416.  

Magrioti V., G. Naxakis, D. Hadjipavlou-Litina, A. Makriyannis, G. Kokotos, (2008), A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity. Bioorg Med Chem Lett., 18(20), 5424-5427.   

Pei Y., R.W. Mercier, J.K. Anday, G.A. Thakur, A.M. Zvonok, D. Hurst, P.H. Reggio, D.R. Janero, A.  Makriyannis, (2008), Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation. Chem Biol., 15(11), 1207-1219.  

Rahn E.J., A.M. Zvonok, G.A. Thakur, A.D. Khanolkar, A. Makriyannnis, A.G. Hohmann, (2008), Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats.  J. Pharmacol. Exp. Ther., 327(2), 584-591.   

Scherma M., J. Medalie, W. Fratta, S.K. Vadivel, A. Makriyannis, D. Piomelli, E. Mikies, J. Haller, S. Yasar, G. Tanda, S.R. Goldberg, (2008), The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.  Neuropharmacology, 54(1), 129-140. 

Sink K.S., P.J. McLaughlin, J.T. Wood, C. Brown, P. Fan, V.K. Vemuri, Y. Pang, T. Olzewska, G.A. Thakur,  A. Makriyannis, L.A. Parker, J.D. Salamone, (2008), The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.  Neuropsychopharmacology, 33(4), 946-955. 

Sink K.S., V.K. Vemuri, T. Olszewska, A. Makriyannis, J.D. Salamone, (2008), Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.  Psychopharmacology (Berl)., 196(4), 565-574.   

Vemuri V.K., D.R. Janero, A. Makriyannis, (2008), Pharmacotherapeutic targeting of the endocannabinoid signaling system:  Drugs for obesity and the metabolic syndrome.  Physiol. Behav., 93(4-5), 671-686.   

Wood J.T., J.S. Williams, L. Pandarinathan, A. Courville, M.R. Keplinger, D.R. Janero, P. Vouros, A.  Makriyannis, C.J. Lammi-Keefe, (2008), Comprehensive profiling of the human circulating endocannabinoid metabolome: clinical sampling and sample storage parameters.  Clin Chem Lab Med., 46(9), 1289-1295. 

Yao F., C. Li, S.K. Vadivel, A.L. Bowman, A. Makriyannis, (2008), Development of novel tail-modified anandamide analogs.  Bioorg. Med. Chem. Lett., 18(22), 5912-5915.

Zvonok N., J. Williams, M. Johnston, L. Pandarinathan, D.R. Janero, J. Li, S.C. Krishnan, A. Makriyannis, (2008), Full mass spectrometric characterization of human monoacyglicerol lipase generated by large-scale expression and single-step purification.  J. Proteome Res., 7(5), 2158-2164.   

Zvonok N., L. Pandarinathan, J. Williams, M. Johnston, I. Karageorgos, D.R. Janero, S.C. Krishnan, A. Makriyannis, (2008), Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis.  Chem. Biol., 15(8), 854-862.  

Gutierrez, T., J.N. Farthing, A.M. Zvonok, A. Makriyannis, A.G. Hohmann, (2007), Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: A comparative analysis.  Br. J. Pharmacol., 150(2), 153-63.

Jaing S., Y. Fu, J. Williams, J. Wood, L. Pandarinathan, S. Avraham, A. Makriyannis, S. Avraham, H.K. Avraham, (2007),  Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS ONE, 2(7), e641.

Jarbe, T.U.C., N.V. Dipatrizio, C. Li, A. Makriyannis, (2007), Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog.  Behav. Pharmacol., 18(7), 673-680.

Janero, D.R., A. Makriyannis, (2007), Targeted modulators of the endogenous cannabinoid system:  Future medications to treat addiction disorders and obesity.  Curr. Psych. Reports, 9(5), 365-373.

Kapur, A., D.P. Hurst, D. Fleischer, R. Whitnell, G.A. Thakur, A. Makriyannis, P.H. Reggio, M.E. Abood, (2007), Mutation studies of S7.39 and S2.60 in the human CB1 cannabinoid receptor: Evidence for a serine induced bend in CB1 transmembrane helix 7.  Mol. Pharmacol., 71(6), 1512-1524.

Karanian, D.A., S.L. Karim, J.T. Wood, J.S. Williams, S. Lin, A. Makriyannis, B.A. Bahr, (2007), Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.  J. Pharmacol. Exp. Ther., 322(3), 1059-1066.

Makriyannis, A., (2007), Cannabinoids as therapeutics.  J. Med. Chem., 50(19), 4785.
Nikas, S.P., G.A. Thakur, D. Parish, S.O. Alapafuja, M.A. Huestis, A. Makriyannis, (2007), A concise methodology for the synthesis of (-)-Δ9-tetrahydrocannabinol and (-)-Δ 9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs. Tetrahedron, 63, 8112-8123.

Papahatjis, D.P., V.R. Nahmias, S.P. Nikas, T. Andreou, S.O. Alapafuja, A. Tsotinis, J. Guo, P. Fan, A. Makriyannis, (2007), C1’-cycloalkyl side chain  pharmacophore in tetrahydrocannabinols.  J. Med. Chem., 50(17), 4048-4060.

Rahn E.J., A. Makriyannis, A.G. Hohmann, (2007), Activation of cannabinoid CB(1) and CB(2) receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.  Br. J. Pharmacol., 152(5), 765-77.

Salamone J.D., P.J. McLaughlin, K. Sink, A. Makriyannis, L.A. Parker, (2007), Cannabinoid CB1 receptor inverse agonists and neutral antagonists:  Effects on food intake, food-reinforced behavior and food aversions.  Physiol. Behav., 91(4), 383-388.

Solinas, M., G. Tandy, Z. Justinova, C.E. Wertheim, S. Yasar, D. Piomelli, S.K. Vadivel, A. Makriyannis, S.R. Goldberg, (2007), The endogenous cannabinoid anandamide produces Δ-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.  J. Pharmacol. Exp. Ther., 321(1), 370-80.

Vadivel, S.K., S. Vardarajan, R.I. Duclos, J.T. Wood, J. Guo, A. Makriyannis, (2007), Conformationally constrained analogues of 2-arachidonoylglycerol.  Bioorg. Med.Chem Lett., 17(21), 5959-5963.

Williams, J., J. Wood, L. Pandarinathan, D.A. Karanian, B.A. Bahr, P. Vouros, A. Makriyannis, (2007), Quantitative method for profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS.  Anal. Chem., 79(15), 5582-5593.

Zvonok N, S. Yaddanapudi, J. Williams, S. Dai, K. Dong, T. Rejtar, B.L. Karger, A. Makriyannis, (2007), Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor.  J. Proteome Res., 6(6), 2068-2079.

Bahr, B.A., D.A. Karanian, S.S. Makanji, A. Makriyannis, (2006), Targeting the endocannabinoid system in treating brain disorders.  Expert Opin Investig Drugs, 15(4), 351-65.

Chen, J.Z., X.W. Han, Q. Liu, A. Makriyannis, J.  Wang, X.Q. Xie, (2006), 3D-QSAR studies of arylpyrazole antagonists of cannabinoid receptor subtypes CB1 and CB2. A combined NMR and CoMFA approach.  J. Med. Chem., 49(2), 625-36.

Dhawan, J., H. Deng,  S.J. Gatley, A. Makriyannis,  T. Akinfeleye, M. Bruneus, A.A. Dimaio, A. N. Gifford, (2006), Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R- [125/131I] AM2233.  Synapse, 60(2), 93-101.

Guo, J., X. Tian, S. Pavlopoulos, A. Makriyannis, (2006), Phospholipid bicelle membrane systems for studying drug molecules.  Handbook of Modern Magnetic Resonance, Edited by G.A. Webb & David Craik. Kluwer Academic Publishers, London, UK.

Ibrahim, M.M., M.L. Rude, N. J. Stagg,  H.P. Mata, J. Lai, T.W. Vanderah, F. Porreca, N.E. Buckley,  A. Makriyannis, R.P. Malan, Jr., (2006), CB2 cannabinoid receptor mediation of antinociception.  Pain, 122(1-2), 36-42.

Jarbe, T.U., R.J. Lamb, Q. Liu, A. Makriyannis, (2006), Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta (9)-THC or (R)-methanandamide (AM-356). Psychopharmacology (Berl.), 188(3), 315-23.

Jarbe, T.U., Q. Liu, A. Makriyannis, (2006), Antagonism of discriminative stimulus effects of delta (9)-THC and (R)-methanandamide in rats.  Psychopharmacology (Berl)., 184(1), 36-45.
Jarbe, T.U., T. Ross, N.V. Dipatrizio, L. Pandarinathan, A. Makriyannis, (2006), Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: Open-field examination in rats.  Pharmacol Biochem Behav., 85 (1), 243-52.

Kim, K., D.H. Moore, A. Makriyannis, M.E. Abood, (2006), AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.  Eur. J. Pharmacol., 542(1-3), 100-5.

Koufaki, M., C. Kiziridi, P. Papazafiri, A. Vassilopoulos, Z. Nagy, A. Farkas, A. Makriyannis, (2006), Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrythmic pharmacophores. Bioorg. Med. Chem., 14(19), 6666-78.

Lu, D., K. Vemuri, R.I. Duclos, Jr., A. Makriyannis, (2006), The cannabinergic system as a target for anti-inflammatory therapies.  Current Topics in Medicinal Chemistry, 6(13), 1401-1426.

McLaughlin, P.J., L. Qian, J.T. Wood, A. Wisniecki, K.M. Winston, L.A.  Swezey, K. Ishiwari, A.J. Betz, L. Pandarinathan, W. Xu, A. Makriyannis, J.D. Salamone, (2006), Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/ inverse agonist AM 1387.  Pharmacol. Biochem. Behav., 83(3), 396-402.

Papahatjis, D.P., V.R. Nahmias, T. Andreou, P. Fran, A. Makriyannis, (2006), Structural modifications of the cannabinoid side chain towards C3-aryl and 1’, 1’-cycloalkyl-1’-cyano cannabinoids.  Bioorg. Med. Chem. Lett., 6(6), 1616-20.

Pavlopoulos, S., G.A. Thakur, S.P. Nikas, A. Makriyannis, (2006), Cannabinoid receptors as therapeutic targets.  Curr. Top Med. Chem., 12(14), 1751-69.

Thakur, G.A., S.P. Nikas, R.I. Duclos, Jr., A. Makriyannis, (2006), Methods for the synthesis of cannabinergic compounds.  Onaivi, E.S. (Ed.), Marijuana and Cannabinoid Research: Methods and Protocols. Humana Press, Inc., Totowa, N.J. 123, 113-48.

Williams J., L. Pandarinathan, J. Wood, P. Vouros, A. Makriyannis, (2006), Endocannabinoid metabolomics: a novel liquid chromatography-mass spectrometry reagent for fatty acid analysis.  AAPS J., 8(4), E655-60.

Willimore, C.B., Kohler, G.D., Makriyannis, A., (2006), Irt>t schedule controlled behavior in ‘learned helpless’ rats: effects from a cannabinoid agonist.  Neuropharmacology, 51(1), 90-101.