The Center for Drug Discovery offers access to a nano-LC- 4000 QTrap (Applied Biosystems) with an ESI source and a TSQ Quantum Ultra Triple Quadrupole (Thermo Scientific) mass spectrometer with both ESI and APCI ion sources and an Agilent 1100 LC frontend.

QTrap
The Center for Drug Discovery Mass Spectrometry laboratory has an ABI QTRAP 4000 mass spectrometer with a nano-LC-MS system on the front end.  This state-of-the-art instrument is the only hybrid quadrupole linear ion trap available on the market and it is extremely sensitive for both protein identification and characterization and small molecule quanitification.  The split-less nano-LC has an exceptionally stable flow rate for reproducible gradients.  This nano-LC system allows us to do multi-dimensional chromatography where ion exchange chromatography or on-line sample clean-up can be performed prior to reverse phase chromatography. 

Quantum
The Center for Drug Discovery Mass Spectrometry laboratory has a Thermo-Finnigan TSQ Quantum Ultra triple quad mass spectrometer, complete with an Agilent 1100 front end.  This instrument has the widest linear dynamic range and highest sensitivity of any triple quad currently on the market, demonstrating detection of our compounds down to the femtogram level.  This instrument is equipped with both an ESI and APCI source and includes metabolite ID software to enhance our pharmacokinetic capabilities.

 

Please contact Sarah Strassburger (s.strassburger@neu.edu) for rates and availability.